Human Protein Atlas - Tissue cell type

The Tissue Cell Type section contains cell type expression specificity predictions for all human protein coding genes, generated using integrated network analysis of publicly available bulk RNAseq data. A specificity classification is used to predict which genes are enriched in each constituent cell type within an individual tissue. The data can be explored on a tissue-by-tissue basis, together with in-house generated immunohistochemically stained tissue sections. In addition, a core cell type analysis focuses on the cell types found in all, or the majority, of the profiled tissues, e.g., endothelial cells or macrophages. Here, genes with predicted specificity in these core cell types in multiple tissues are detailed. More information about the specific content and data analysis in the section can be found in the Methods Summary.

Learn about:

if a gene is predicted to have cell type specificity within a given tissue
which genes have a common cell type specificity prediction within each tissue
the catalogue of genes with predicted specificity in core cell types across tissues

该组织细胞类型部分包含了针对所有人类蛋白质编码基因的细胞类型表达特异性预测结果，这些预测结果是通过整合公开可用的批量RNA测序数据进行的网络分析生成的。通过特异性分类，预测了哪些基因在每个个体组织中的构成细胞类型中富集。数据可按组织逐个组织地探索，并与内部生成的免疫组化染色组织切片相结合。此外，核心细胞类型分析专注于所有或大多数被分析组织中的细胞类型，例如内皮细胞或巨噬细胞。在此，详细描述了在多个组织中这些核心细胞类型中具有预测特异性的基因。关于该部分的特定内容和数据分析的更多信息，可在方法摘要中找到。了解以下内容：若某个基因在特定组织中预测具有细胞类型特异性；每个组织中具有共同细胞类型特异性预测的基因；以及跨组织中具有预测特异性的基因目录。