Crystal structure of humanised cereblon from Magnetospirillum gryphiswaldense bound by dihydrouracil-indole compound [1-(1H-indol-6-yl)dihydro-2,4(1H,3H)-pyrimidinedione].

Crystal structure of humanised cereblon from Magnetospirillum gryphiswaldense bound by dihydrouracil-indole compound [1-(1H-indol-6-yl)dihydro-2,4(1H,3H)-pyrimidinedione]. Descriptor: 1-(1H-indol-6-yl)-1,3-diazinane-2,4-dione, Cereblon isoform 4, ZINC ION Authors: Collie, G.W. Deposit date: 2024-08-22 Release date: 2025-09-03 Last modified: 2026-06-03 Method: X-RAY DIFFRACTION (1.393 Å) Cite: A dihydrouracil CRBN ligand mitigates IMiD associated safety liabilities in heterobifunctional targeted protein degrader. Nat Commun, 17, 2026