Effect of Trpc1 or Trpc6 knockout on gene expressions in the hearts of endotoxemic mice. Effect of Trpc1 or Trpc6 knockout on gene expressions in the hearts of endotoxemic mice

To investigate the mechanism of TRPC1 or TRPC6 on the regulation of endotoxemic cardiac dysfunction, we established Trpc1-/- and Trpc6-/- mice. LPS-challenged endotoxemic mouse model was built, and the gene expression profile was analyzed using data obtained from RNA-seq of WT, LPS-challenged WT, LPS-challenged Trpc1-/-, and LPS-challenged Trpc6-/- mice hearts. Overall design: Comparative gene expression profiling analysis about RNA-seq data for three mice hearts of control and endotoxemic mouse model. The groups are as follows, WT+vehicle, WT+LPS, Trpc1-/-+LPS, and Trpc6-/-+LPS.