Differential Expression Spectrum of tRNA fragments in Alzheimer's Disease

We report the profiling of tRNA fragments from the temporal cortex of controls and late-stage Alzheimer's disease subjects. We show tRNA fragments expression changes between the two groups. Four upregulatedtRNA fragments in the results of Real Time-qPCR were consistent with the small RNA microarray:5'tRF_GluCTC, 5'tRF_GluTTC, 5'tRF_GlyGCC, 5'tRF_GlyCCC Small RNA microarray on five pairs of temporal cortex of Alzheimer's Disease patients and healthy controls