Metagenomic sequencing of T2D patients

Human gut microbiota have been proved to associate with multiple human chronic disease. The gut microbiota has been found associated with pre-diabetes and type 2 diabetes, however the association between gut microbiota and the development of cardiovascular disease in T2D patients is not clear. By comparing the metagenomes of healthy, T2D and T2D-CVD patients, we found the enrichment of K. pneumoniae strains were associated with T2D-CVD patients by producing TMA and virulence factors.