Quantitative trait loci are associated with vaccine-induced protection against M.tb.

Each QTL that reached a significant or suggestive cutoff was annotated as a vaccine-induced protection, “Vip”, locus. Traits with QTL with overlapping confidence intervals and similar peak positions were grouped into a presumed putative shared QTL. Cytokine QTL are shaded in grey. Values in bold are those that were significant, p < 0.05. a Pos.; the position on the chromosome for the QTL peak, in Mb. b LOD; the logarithm of odds (LOD) value determined at each QTL peak. c CI; the confidence interval (CI) for each QTL region, in Mb. d % variance describes the total variance that is attributable to genetic differences. e Weight loss was calculated as the percent weight loss between body weight at euthanasia/body weight at peak.