Visible-Light-Induced Synthesis of 1,2-Dicarboxyl Compounds from Carbon Dioxide, Carbamoyl-dihydropyridine, and Styrene

β-Amidated
carboxylic acids, or succinamic acid derivatives,
constitute a valuable chemical scaffold with broad applications in
pharmaceuticals, agrochemicals, and polymer sciences. Herein, we report
a redox-neutral multicomponent reaction for the synthesis of succinamic
acid derivatives in good yields. This protocol involves styrene, CO2 and 1,4-carbamoyl-dihydropyridine as radical precursors.
The method exhibits a broad substrate scope under mild reaction conditions,
including late-stage functionalization. Moreover, by employing 13CO2, the method enables the synthesis of labeled
1,2-dicarboxylic compounds.