BIOGRID CURATED DATA FOR DPY-22 (Caenorhabditis elegans)

Protein-Protein, Genetic, and Chemical Interactions for DPY-22 (Caenorhabditis elegans) curated by BioGRID (https://thebiogrid.org); DEFINITION: dpy-22 encodes a broadly expressed protein, homologous to the human transcriptional mediator protein TRAP230, which is involved in WNT and RAS signaling, as well as in dosage compensation; DPY-22 has a C-terminal glutamine-rich domain that is dispensable for inhibition of RAS-dependent cell differentiation, but is required for inhibition of BAR-1-dependent gene expression.

DPY-22 的蛋白质-蛋白质、遗传和化学相互作用数据集，由 BioGRID 精心整理（https://thebiogrid.org）；定义：dpy-22 基因编码一种广泛表达的蛋白质，与人类转录中介蛋白 TRAP230 同源，该蛋白参与 WNT 和 RAS 信号通路，以及剂量补偿过程；DPY-22 蛋白的羧基末端富含谷氨酰胺结构域，对于抑制 RAS 依赖性细胞分化并非必需，但对于抑制 BAR-1 依赖性基因表达则是必需的。