Oral administration of vanillin improves imiquimod-induced psoriatic skin inflammation in mice: the involvement of interleukin-23/interleukin-17 axis

Vanillin is one of the most widely used flavouring products worldwide. Psoriasis is a chronic inflammatory skin disorder. Here we analyzed the effect of vanillin on imiquimod (IMQ)-induced psoriatic skin inflammation in mice. Mice were treated topically with IMQ and/or orally with 100 mg/kg vanillin for 7 consecutive days. RNA was extracted from skin tissues. The gene expression profiles were further analyzed by microarray.