Gene expression profile at single cell level of tumor infiltrating myeloid antigen presenting cells from tonsillar cancer patients

Myeloid antigen presenting cells are a heterogeneous population, and their identity is greatly influenced by niche specific cues. We used single cell RNA sequencing (scRNA-seq) to analyze the diversity of myeloid antigen presenting cells in tonsillar cancer tissue and paired contralateral healthy tissue. Overall design: Myeloid antigen presenting cells from tonsillar cancer patients were isolated by Fluorescence-activated cell sorting (FACS) according to the presence of CD13 and HLA-DR and analyzed using scRNAseq.