Nutmeg-Derived Natural Product Hybrids: Synthesis and Investigations of Their Antibacterial Activity and Mechanism of Action

This thesis focuses on developing new hybrid compounds to fight bacteria. The most potent compound identified in this study, 4OHA_CIP, shows very strong antibacterial activity, especially against gram-positive strains. More importantly, it is also active against drug-resistant bacteria. Overall, this research highlights a promising strategy for designing new antibiotics that could help combat the growing problem of antibiotic resistance and in turn, improve public health.