A Full Window Data Independent Acquisition Method for Deeper Top-down Proteomics
收藏国家人口健康科学数据中心2026-06-01 收录
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https://www.ncmi.cn/phda/dataDetails.do?id=CSTR:17970.11.A001G.202410.366.V1.0
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资源简介：
In this study, we present a novel Full Window DIA (FW-DIA) method designed to address the challenges associated with data-independent acquisition in top-down proteomics. The FW-DIA approach significantly enhances fragment signal intensities by approximately 50-fold and increases protein sequence coverage threefold. The efficacy of FW-DIA was demonstrated through the analysis of a five-protein mixture under native conditions, as well as ribosomal proteins from Escherichia coli (E. coli).
提供机构：
北京蛋白质组研究中心
创建时间：
2024-10-30
