A Full Window Data Independent Acquisition Method for Deeper Top-down Proteomics
收藏国家人口健康科学数据中心2026-06-01 收录
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In this study, we present a novel Full Window DIA (FW-DIA) method designed to address the challenges associated with data-independent acquisition in top-down proteomics. The FW-DIA approach significantly enhances fragment signal intensities by approximately 50-fold and increases protein sequence coverage threefold. The efficacy of FW-DIA was demonstrated through the analysis of a five-protein mixture under native conditions, as well as ribosomal proteins from Escherichia coli (E. coli).
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北京蛋白质组研究中心创建时间：
2024-10-30
