Cellular Phenotype database

The Cellular Phenotype database stores data derived from high-throughput phenotypic studies and it is being developed as part of the Systems Microscopy Network of Excellence project. The aim of the Cellular Phenotype database is to provide easy access to phenotypic data and facilitate the integration of independent phenotypic studies. Through its interface, users can search for a gene of interest, or a collection of genes, and retrieve the loss-of-function phenotypes observed, in human cells, by suppressing the expression of the selected gene(s), through RNA interference (RNAi), across independent phenotypic studies. Similarly, users can search for a phenotype of interest and retrieve the RNAi reagents that have caused such phenotype and the associated target genes. Information about specific RNAi reagents can also be obtained when searching for a reagent ID.

细胞表型数据库存储了来自高通量表型研究的衍生数据，该数据库作为卓越系统显微镜网络项目的一部分正在开发中。细胞表型数据库的目的是提供对表型数据的便捷访问，并促进独立表型研究的整合。通过其用户界面，用户可以搜索感兴趣的基因或基因集合，并检索通过RNA干扰（RNAi）抑制所选基因（或基因集合）表达而在人类细胞中观察到的功能丧失表型，这些数据来源于独立表型研究。同样，用户可以搜索感兴趣的表型，并检索导致此类表型的RNAi试剂及其相关靶基因。在搜索试剂ID时，还可以获取特定RNAi试剂的信息。