Differentially expressed genes of Peromyscus leucopus fibroblast cultures treated with lipopolysaccharide or buffer alone

This experiment and its results were part of a larger study of the
differential responses of the white-footed deermouse Peromyscus leucopus
and the house mouse Mus musculus to single injections
of lipopolysaccharide (LPS). The entire study is
presented in the associated manuscript in submission and in the
listed pre-print. The aim of this particular experiment was to identify
differentially expressed genes (DEG) of fibroblast cultures of P.
leucopus. The experiment identified 543 DEGs that were either upregulated
or down-regulated in response to four hours' exposure to LPS. The
accompanying dataset identifies these DEGs and gives the fold-change of
LPS-treated over control samples as well as the false-discovery rate (FDR)
p value. For protein coding sequences the 10 highest TPMs in order among
control samples were ferritin heavy chain (Fth), Slpi, secreted protein
acidic and cysteine rich (Sparc), eukaryotic translation elongation factor
1 alpha (Eef1a1), ferritin light chain (Ftl), vimentin (Vim), serpin
family H member 1 (Serpinh1), ribosomal protein lateral stalk subunit P1
(Rplp1), collagen type I alpha 1 chain (Col1a1), and Gapdh. There were 324
genes that were up-regulated by criterion of fold-change ≥ 4 and FDR
< 0.05, and 17 genes that were down-regulated, with an additional
80 down-regulated by criterion of fold-change ≥ 2 and FDR < 0.5.
Among those displaying the marked increases in expression between the
control and LPS conditions were two subunits of nuclear factor kappa B
(Nfkb), two forms of Saa, Nos2, Csf3, Sod2, and Pla2g2a.