TNF neutralization-associated parameters, definitions, and values.

*Diffusion coefficient of the drug in granuloma was estimated in line with estimates for diffusible factors of similar molecular weight in tumors [88], [89]. †Drug permeability in granuloma was estimated based on permeability of bifunctional antibodies in tumors [94]. ‡Drug concentration in the lung was estimated based on approximate blood concentration of TNF-neutralizing drugs. For most antibodies, tissue/blood concentration ratios are in the range of 0.1–0.5 [95].