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Neonatal T helper 17 responses are skewed towards an immunoregulatory interleukin-22 phenotype

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE135467
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We report broad developmental differences in gene expression profiles between neonatal (term) and adult naive CD4 T cells, resulting in non-stereotypic Th17 differentiation responses to TGF-beta. Total RNA obtained from naïve CD4 T cells (CD3+CD4+CD45RO-CCR7+CD25-) isolated by Fluorescent Activated Cell Sorted (FACS) from 12 neonates (cord blood) and 12 adults (peripheral blood) donors.
创建时间:
2021-05-25
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