Lipopolysaccharide inhalation recruits monocytes and dendritic cell subsets DC2,3 and DC5 to the alveolar airspace

Using lipopolysaccharide inhalation to induce acute inflammation in healthy volunteers and examine the impact on bronchoalveolar lavage (BAL) fluid and blood MP repertoire. This study defines the characteristics of human DCs and monocytes recruited into bronchoalveolar space immediately following localised acute inflammatory stimulus in vivo. 54 samples were analyzed in total, including 23 LPS BAL samples across 6 cell types, 14 Saline solution controls across 4 cell types and 17 healthy control blood samples across 6 cell types.