Transcriptomic Analysis of Rat Cerebral Cortex Reveals the Potential Mechanism of Electroacupuncture Opening Blood Brain Barrier

Therapeutic treatment options for central nervous system (CNS) diseases are greatly limited by the blood-brain barrier (BBB). Electroacupuncture (EA) can be used to induce an increase in BBB permeability on rats, providing a potential approach for the delivery of drugs from the systemic circulation into the brain. However, there remains a large gap in our knowledge regarding the impact of EA on brain gene expression. This work is focused on investigating the transcriptional changes of rat cerebral cortex following EA and expression changes in genes and bioinformatic analysis was performed. Our results provide a valuable resource that will guide mechanism research of EA opening BBB and other ways to mediate drug delivery into the brain.中枢神经系统（central nervous system, CNS）疾病的治疗方案极大受限于血脑屏障（blood-brain barrier, BBB）。电针（Electroacupuncture, EA）可诱导大鼠血脑屏障通透性升高，为药物从体循环递送进入大脑提供了潜在可行途径。然而，学界对电针对大脑基因表达的影响仍存在显著认知空白。本研究聚焦于探究电针刺激后大鼠大脑皮层的转录组变化，分析基因表达差异并开展生物信息学分析（bioinformatic analysis）。本研究结果可为电针开放血脑屏障的机制研究，以及其他介导药物入脑的相关策略提供宝贵的研究资源与理论指导。