Vascular Density.

Using the computer-assisted stereological toolbox system, the number and the diameter of vessels were measured based on immunohistochemical staining for collagen type 4 at 10 days after MCAO. The number of the larger capillaries (>10 μm) was significantly higher in the MSC 1-hour group than the control (P = 0.036) (A). After the intracerebrolventricular administration of a selective MMP-2 inhibitor or placebo, vascular density was not significantly different in all ranges of vessel diameter (B).