1,4-Addition Ugi Reaction Using Cyclic α,β-Unsaturated Ketone as Substrate
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https://figshare.com/articles/dataset/1_4-Addition_Ugi_Reaction_Using_Cyclic_-Unsaturated_Ketone_as_Substrate/3856011
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A four-component, 1,4-addition Ugi reaction using cyclic α,β-unsaturated ketones, carboxylic acids, amines, and isocyanides was developed for the first time. By combining this reaction with Michael addition, nucleophilic substitution, and C–N bond formation reactions, bicyclic and tricyclic scaffolds with pyridinone and quinolinone moieties, two basic units among a variety of natural products and pharmaceuticals, were constructed.
创建时间:
2016-10-03



