Summary of the results.

The effects of the expression of the semaphorins in the four tumor cell lines on tumor development, tumor angiogenesis and on the anchorage free growth of the cells are summarized. The relative expression levels of the relevant semaphorin binding receptors in each of the cell lines are shown as well (High level expression: +++, Low level expression: +). N.D., not determined.
*MDA-MB-231 derived tumors expressing sema3A and tumors derived from MDA-MB-435 expressing sema3F and sema3G did not develop and it was therefore not possible to measure effects on tumor angiogenesis.
**Estimation of the relative expression levels of plexD1 is based on estimation of mRNA levels.
***Sema3F binds to np1 with a 10 fold lower affinity as compared to its affinity for np2 but it is unclear whether np1 can transduce sema3F signals.