Transcriptomic signatures of SARS-CoV-2 and Influenza virus infections

Blood gene-expression was measured in 103 patients infected with SARS-CoV-2 (collectively named “COVID-19”) and compared to that of 22 patients infected with Influenza A or B (INFL) as well as 27 non-infected, healthy individuals (HLTY) COVID-19 patients were stratified according to the level of respiratory failure; 23 did not require oxygen support (“OXY0”), 40 received oxygen but no mechanical ventilation (“OXY1”) and 40 required mechanical ventilation (“TUBE”). In the latter group, 15 patients were sampled within the first 7 days in hospital (“TUBE early”) while 25 were sampled later (“TUBE late”).