Rh(III)-Catalyzed Cascade Oxidative Olefination/Cyclization of Picolinamides and Alkenes via C–H Activation

Rh­(III)-catalyzed
cascade oxidative alkenylation/cyclization of
picolinamides and alkenes to furnish pyrido pyrrolone derivatives
is described, in which three C–H bonds and one N–H bond
broke, while one C–C bond and one C–N bond formed. The
reaction proceeded with high yield and high regioselectivity and stereoselectivity.
Moreover, copper acetate can also be used in catalytic amounts with
O2 serving as the terminal oxidant.