The crystal structure of FAN1 Nuclease bound to 5' phosphorylated p(dG)/3'(dT-dT-dT-dT) double flap DNA

The crystal structure of FAN1 Nuclease bound to 5' phosphorylated p(dG)/3'(dT-dT-dT-dT) double flap DNA Descriptor: CALCIUM ION, CHLORIDE ION, DNA (5'-D(*AP*AP*CP*AP*CP*GP*CP*CP*TP*AP*GP*AP*CP*TP*CP*CP*TP*CP*A)-3'), ... Authors: Aretz, J, Jeyasankar, G, Salerno-Kochan, A, Thomsen, M, Thieulin-Pardo, G, Haque, T, Monteagudo, E, Felsenfeld, D, Finley, M, Vogt, T.F, Boudet, J, Prasad, B.C. Deposit date: 2024-02-23 Release date: 2025-03-05 Last modified: 2025-07-09 Method: X-RAY DIFFRACTION (2.645 Å) Cite: A FAN1 point mutation associated with accelerated Huntington's disease progression alters its PCNA-mediated assembly on DNA. Nat Commun, 16, 2025