Pd-Catalyzed Allylic Alkylation of CF3-Containing Esters with Three Electron-Withdrawing Groups
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http://www.thieme-connect.com/DOI/DOI?10.1055/s-0032-1318313
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资源简介：
Tsuji–Trost reaction (Pd-catalyzed allylic alkylation) of CF3-containing esters with three electron-withdrawing groups is reported. The reactions with methyl bis(trifluoromethyl)acetate and dimethyl (trifluoromethyl)malonate were carried out with low-loading catalysts of Pd(0) and XPhos at ambient temperature in THF, giving the products in high yields. This method efficiently overcomes the β-defluorination, which is hard to control in the chemical transformation of α-trifluoromethyl carbanions, and provides versatile fluorinated compounds with quaternary carbon centers, which are highly demanded in drug discovery.
提供机构：
© Georg Thieme Verlag
创建时间：
2013-03-01
