Single_cell_transcriptomics_of_malaria_parasites. Single_cell_transcriptomics_of_malaria_parasites

Single-cell RNA-sequencing (scRNA-seq) offers the opportunity to examine transcriptional variation within populations of apparently homogeneous cells. We developed an optimised protocol to assess variability across individual Plasmodium parasites, and then use scRNA-seq to uncover variation in unicellular eukaryotic organisms for the first time. We find that several gene families important for immune evasion in the mammalian host are also employed during transmission to the mosquito. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/