human adenovirus 18 and adeno-associated virus 2 detected in an immunocompromised individual

Patients undergo allogeneic hematopoietic stem cell transplantation (HSCT) often experience a significant reduction in immune function, and thus are more vulnerable to experiencing a more severe infection. In this study, we reported a complete human adenovirus 18 (AdV18) and adeno-associated virus 2 (AAV2) from a patient with hematopoietic stem cell transplantation. The AdV18 and AAV2 reported in our study showed 99.3% and 97.3% nucleotide identities with the previously reported ones, respectively. We documented the concurrent presence of non-replicative AAV2 along with its potential helper viruses AdV18 in fecal specimen from the patient following HSTC. Furthermore, we successfully obtained a full-length sequence for AdV18 - marking only the second complete genome sequence within the resources.