Slow transcription of the 99a/let-7c/125b-2 cluster results in differential miRNA expression and promotes melanoma phenotypic plasticity

Melanoma initiates within the epidermis; during progression, cells invade into the dermis andbecome metastatic through the lymphatic system. Prior to melanoma cells invasion into thedermis, an increased density of dermal lymphatic vessel is observed, generated by not fullyunderstood mechanism.The following is a high-throughput profiling of mRNA extracted from invasive and proliferative melanosomes, some treated with miR let-7c/99a/125b2.