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Single cell RNA-seq analysis of endothelial cells during diabetic atherosclerosis

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE248065
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Single-cell RNA sequencing (scRNA-seq) was performed on the CD31-mircrobeads enriched endothelial cells isolated from aorta and heart from eight-week-old, male Klf11f/f-Ldlr-/- and Klf11ECKO-Ldlr-/- (Klf11flf-Tie2Cre-Ldlr-/-) mice fed a diabetogenic high-fat diet with 0.15% cholesterol (DDC) diet for 12 weeks. This study report the changes of EC subpopulations, fractions and transcriptomics during diabetic atherosclerosis. Examination of the transcriptomic profiles of endothelial cells isolated from aorta and heart pooled from three Klf11f/f-Ldlr-/- or Klf11ECKO-Ldlr-/- mice fed a diabetogenic diet with 0.15% cholesterol (DDC) diet for 12 weeks
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2024-10-21
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