Mapping enhancer-gene regulatory interactions from single-cell data

We generated single-cell 10x Multiome data (ATAC-seq and RNA-seq) from various stages of hiPSC differentiation into hepatic progenitor cells. We used this dataset to benchmark the scE2G model and other single-cell enhancer–gene prediction models against a gold-standard CRISPR perturbation dataset. Overall design: We generated single-cell 10x Multiome data (ATAC-seq and RNA-seq) from various stages of hiPSC differentiation into hepatic progenitor cells. We used this dataset to benchmark the scE2G model and other single-cell enhancer–gene prediction models against a gold-standard CRISPR perturbation dataset.