Adverse impact of paternal age on embryo euploidy: insights from retrospective analysis and interpretable Machine learning

The trend of delayed childbearing has increased the average age of parents, with the impact of paternal age on embryo euploidy remaining controversial. Therefore, this study aimed to investigate the impact of paternal age on embryo euploidy using retrospective clinical data and interpretable machine learning. This retrospective study included 960 couples and 4,718 embryos undergoing preimplantation genetic testing for aneuploidy (PGT-A). Couples were divided into two groups based on paternal age (Group 1 ≥ 40 years and Group 2 P P