Regio- and Stereoselective Glycosylation: Synthesis of 5-Haloimidazole α-Ribonucleosides
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https://figshare.com/articles/dataset/Regio_and_Stereoselective_Glycosylation_Synthesis_of_5_Haloimidazole_Ribonucleosides/3074416
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资源简介：
We describe the synthesis of novel 5-haloimidazole ribonucleosides as precursors of modified cobalamins. A regio-
and stereoselective glycosylation of protected ribose with
silylated 4(5)-haloimidazoles produces 5-haloimidazole ribonucleosides predominantly in the α-configuration (60−75%) without any 4-substituted imidazole ribonucleoside.
The structure of the 5-fluoroimidazole ribonucleoside was
confirmed by X-ray crystallography and 2D NMR spectroscopy.
创建时间：
2016-03-01
