Guidance Document on Using Cytotoxicity Tests to Estimate Starting Doses for Acute Oral Systematic Toxicity Tests
收藏Organisation for Economic Co-operation and Development2026-03-28 收录
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This Guidance Document describes methods to determine the in vitro basal cytotoxicity of test substances using NRU assays and the use of the in vitro data to determine starting doses for in vivo acute oral systemic toxicity tests. The NRU assay is performed in a dose-response format to determine the concentration that reduces NRU by 50% compared...
