Geometric Parameterization of Histological Cross-Sections.

FCSA = fiber cross-sectional area. MDSA = myonuclear domain surface area. FSAV = total muscle fibre surface area per tissue volume. CCSA = capillary cross-sectional area (EC+lumen). ECSA = endothelial cell surface area. ESAV = total endothelium surface area per tissue volume. IS = interstitial space. IF = interstitial fluid. *calculated. † = combined volume of lateral gastrocnemius, medial gastrocnemius, and soleus muscles (unilateral calf). †† = approximated by collagen content. ‡calculated for average partition coefficients of 0.85 in ECM and 0.325 in BM (see Table 1b).