aMacaques were inoculated with one of five different inocula, SIVsmE543-3 (E543-3), SIVsmH635FC (H635FC), SIVmac239 (mac239), or plasma from SIVsmH445-infected macaques, H635+H631 (plasma). LDN, lymph
All vaccinated mice were intranasally (i.n.) challenged with 30 µl 105 TCID50/ml of the CA/04/09 virus 2 weeks after the last immunization. Lung tissue samples were obtained at 2, 4, 6, and 8 days of
*n.d. = non-detectable.- Humanized mice were sacrificed 151 days after HIV infection and 114 days after starting ART or double long-acting drugs.- Detection limit: the volume of plasma available was s
The SCID-hu mouse is a small animal in which human hematolymphoid organs can be engrafted and maintained in vivo. In this study, parameters are described for reproducible infection of SCID-hu mice aft