ANGPTL7 allelic series association summary in UK Biobank and FinnGen.

Variant: the rs identifier (rsID), the amino acid nomenclature (HGVSp), and genomic coordinate (CHR for chromosome and POS for the position in hg19), as well as reference (REF) and alternate (ALT) alleles, are shown. Dosage—genotype of individuals for protein and nucleotide sequences. Carrier frequency—carrier frequency in UK Biobank (UK) and FinnGen (Finland) for the respective genotype dosage. N with IOP—number of individuals in UK Biobank with intraocular pressure measurements corresponding to the genotype dosage. Effect size estimates—reported effect size estimates. IOP (mmHg) [95% CI]—unstandardized estimates of effect size on corneal-compensated and Goldmann-correlated intraocular pressure measurements (NB: standardized estimated effect sizes may have lower p-values due to normalization procedure). OR for glaucoma—estimate odds ratio on glaucoma risk for the respective genotype dosage. NS non-significant (p > 0.1). Effect sizes always reported with respect to alternate allele dosage.