Transcriptome-wide cis-eQTL Mendelian randomisation and cross-tissue prioritisation in vascular dementia: derived data and reproducibility archive

This repository contains derived results, analysis scripts, validation records, supplementary tables, and supplementary figures supporting the study “Transcriptome-wide cis-eQTL Mendelian randomisation and cross-tissue prioritisation in vascular dementia.” The study performed a complete FinnGen R13 blood cis-eQTL Mendelian-randomisation screen, audited all experiment-wide corrected loci, characterised a GTEx frontal cortex BA9 cross-tissue candidate set, conducted full-cis colocalisation and local transcript competition analyses, and assessed eight priority genes across 12 non-BA9 GTEx v8 brain regions. The repository includes derived MR and colocalisation results, candidate-level evidence audits, targeted multi-brain-region results, validation outputs, Supplementary Tables S1–S20, Supplementary Figures S1–S6, a STROBE-MR checklist, analysis code, data dictionaries, and file-integrity manifests. Provider-controlled source data from eQTLGen, FinnGen, GTEx, the 1000 Genomes Project, eQTL Catalogue, GWAS Catalog, GEO, and CZ CELLxGENE are not redistributed. Instructions and persistent links for obtaining the source data are provided in the archive. The corrected blood findings should be interpreted as one-SNP locus-level signals. SMPD2 is one of four rule-selected exploratory cases. The targeted non-BA9 analysis represents dependent cross-tissue robustness rather than independent replication and does not establish robust colocalisation, transcript specificity, therapeutic validity, or independent outcome replication.