Cyclosporin ameliorates right ventricular remodeling of postnatal mice with volume overload.

We reported the RNAseq analyses of right ventricular free wall of myocardium in three groups of mice(3 in each group)at postnatal day 14 (P14). The mice in volume overload (VO) group underwent an abdominal surgery by puncture from aorta to inferior vena cava at P7, mice in Sham group underwent the same surgery except for the puncture. The mice in CsA group were VO mice who were also injected with cyclosporin A(CsA) for seven days. The results revealed that there were differentially expressed genes between VO and sham group at P14, Inhibiting the immune response with CsA caused the gene expression profile of VO mice to shift towards that of sham mice. Overall design: RNAseq analyses of right ventricular myocardium in volume overload, CsA treated and sham-operated postnatal mice.