Changes in cell cycle pattern in bone marrow and spleen erythroid cells after paraquat treatment.

Mice were treated with repeated doses (10 mg/kg) of paraquat on alternate days. Bone marrow/spleen cells were harvested after 14 days of exposure and stained with anti-mouse Ter 119-FITC and propidium iodide followed by flow cytometric analysis. Ter119+ve cells were gated and cell cycle analysis was done on gated cells by utilizing Modfit-LT software. Each value represents mean ± SEM of data from 5–6 mice. *p<0.05 Standard t test, comparisons of cells in different phases of cell cycle in control and paraquat treated mice.