Disruptions of Topological Chromatin Domains Causes Pathogenic Rewiring of Gene-Enhancer Interactions

ChEBI2015-05-08 更新2026-07-21 收录

染色体三维结构

增强子-基因互作

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Disruptions of Topological Chromatin Domains Causes Pathogenic Rewiring of Gene-Enhancer Interactions

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2015-05-08

Three-dimensional localization and tracking of chromosomal loci throughout the Escherichia coli cell cycle

染色体三维结构

活细胞成像

The intracellular position of genes may impact their expression, but it has not been possible to accurately measure the 3D position of chromosomal loci. In 2D, loci can be tracked using arrays of DNA-

DataCite Commons2025-01-15 更新100

Source Data Extended Data Figure 1c

染色体三维结构

基因调控机制

This file contains the source data for Extended Data Figure 1c. c, Hi-C matrix (at 5 kb resolution) and loops at the MRR1 region showing two looping silencers (S1 and S2) that exhibit chromatin intera

NIAID Data Ecosystem60

Chromatin architecture landscape in hierarchical hematopoietic cells

染色体三维结构

造血细胞分化

The spatiotemporal chromatin reorganization during hematopoietic differentiation has not been well characterized, which partly limited by the large amounts of starting cells for the current high-throu

NIAID Data Ecosystem60

Condensin DC spreads linearly and bidirectionally from recruitment sites to create loop-anchored TADs in C. elegans (ChIP-seq and Hi-C data). Condensin DC spreads linearly and bidirectionally from recruitment sites to create loop-anchored TADs in C. elegans (ChIP-seq and Hi-C data)

染色体三维结构

环挤压

Inspection of Hi-C and ChIP-seq data suggests that condensin DC is an X-chromosome enriched loop extruder that stalls at rex sites. Insertion of rex site on X-chromosome suggests orientation independe

NIAID Data Ecosystem70

Condensin DC spreads linearly and bidirectionally from recruitment sites to create loop-anchored TADs in C. elegans. Condensin DC spreads linearly and bidirectionally from recruitment sites to create loop-anchored TADs in C. elegans

染色体三维结构

拓扑关联域形成

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

NIAID Data Ecosystem60