Association between GUCY1A3/GUCY1B3 single nucleotide polymorphisms (SNPs) and POAG in the Glaucoma Gene and Environment (GLAUGEN) study.

Most significant single nucleotide polymorphisms (SNPs) stratified by gender and type of visual field (VF) loss. 51 SNPs were analyzed within the GUCY1A3/GUCY1B3 locus and 50 kb upstream and downstream of the region. A Bonferroni correction of 3.3×10−4, correcting for analyzing 51 SNPs and 3 subgroups, was applied to define statistical significance. The top SNP (rs11722059) reached significance in women with paracentral visual field (VF) loss (P value of 3.1×10−4, bold and italicized). MA: minor allele; OR: multivariable odds ratio associated with each minor allele dose, generated by multiple logistic regression analyses adjusting for age, gender, study site, DNA source, DNA extraction method, and three eigenvectors; CI: confidence interval; Chr: chromosome; N: number.