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Transcriptional landscape changes after tolerization adaptive laboratory evolution of Staphylococcus aureus to vancomycin

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE149213
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Eight vancomycin-tolerized strains were selected for transcriptional analysis, along with their pre-evolved counterparts (wild type and one media-adapted strain per medium type). Strains were grown in RPMI or CA-MHB respective to the evolution media, with and without vancomycin (at 1/2 MIC). At OD 0.2, cultures without vancomycin were harvested. At the same OD, cultures were treated with 0.5x MIC of vancomycin, and harvested for RNA 30min after.
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2021-07-14
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