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Highly Stereoselective Brønsted Acid Catalyzed Synthesis of Spirooxindole Pyrans

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Figshare2016-02-23 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Highly_Stereoselective_Br_nsted_Acid_Catalyzed_Synthesis_of_Spirooxindole_Pyrans/2641129
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A Brønsted acid-catalyzed Prins-type cyclization sequence to construct spirooxindole pyrans in high yields and excellent diastereoselectivity has been developed. The combination of a β-hydroxy dioxinone fragment and isatin dimethyl acetal generate oxa-spirooxindoles efficiently. These compounds are diversifiable scaffolds that tap into the rich chemistry of dioxinones.
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2016-02-23
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