Genome-wide identification and characterization of circular RNA m6A modification in pancreatic cancer

N6-methyladenosine (m6A) is the most abundant modification of RNA in eukaryotic cells and play critical roles in cancer. While most related studies focus on m6A modifications in linear RNA, transcriptome-wide profiling and exploration of m6A modification in circular RNAs in cancer is still lacking. Here, we proposed a high-performance tools named Circm6A for the detection of m6A-circRNAs. Based on Circm6A results, we revealed the m6A-circRNAs genomic landscape of PDAC for the first time and shed new light on the regulatory aspect of circRNAs at the RNA epigenetic level. 77 tissue samples were collected from PDAC patients for m6A-seq, including 53 tumor samples and 24 normal samples. *** The GEO submission contains only processed data (raw counts tables). Raw data has been submitted to GSA (The Genome Sequence Archive, China), due to patient privacy concerns and human genetic resources policy in China.