Corticothalamic communication under analgesia, sedation and gradual ischemia: a multimodal model of controlled gradual cerebral ischemia in pig

Brain injuries and ensuing neurological abnormalities due to chronic hypoxia are among the most frequent causes and difficult to detect reliably. Prevention strategies require novel accurate methods. We showed that electrocorticogram's mutual information properties (ECoG) contain information about corticothalamic communication, which can be quantified without invasive insertion of the thalamic electrodes.Here we present the method and the data set to derive ECoG/EEG biomarkers of corticothalamic communication under normal, sedation and hypoxic/ischemic conditions.We hypothesize that the proposed biomarkers of corticothalamic communication derived from EEG alone will signal increased risk for or an imminent brain injury from short periods of data (less than 10 min).We present signal-analytical approaches to derive a signature of coupling between the ECoG and electrothalamogram (EThG) signals that were recorded under conditions of gradual ischemia in juvenile pigs.We hope this data set will contribute to development of new brain monitoring technologies to improve prevention of neurological injuries.All experiments have been approved by the responsible animal ethics committee.<br>BIDS version of the dataset can also be found on OpenNeuro: DOI:10.18112/openneuro.ds003380.v1.0.0<br>Publication: https://www.nature.com/articles/s41597-020-00781-y