five

Dibenzosuberone inhibitor 8e in complex with p38 MAPK

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Protein Data Bank Japan2024-05-08 更新2026-03-21 收录
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Dibenzosuberone inhibitor 8e in complex with p38 MAPK Descriptor: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, ~{N}-[2,4-bis(fluoranyl)-5-[[14-(2-hydroxyethylcarbamoyl)-2-oxidanylidene-6-tricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3(8),4,6,11,13-hexaenyl]amino]phenyl]thiophene-2-carboxamide Authors: Buehrmann, M, Rauh, D. Deposit date: 2017-01-11 Release date: 2017-09-06 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Design, Synthesis, and Biological Evaluation of Novel Type I(1)/2 p38 alpha MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine. J. Med. Chem., 60, 2017
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2017-01-11
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