Library of Integrated Network-Based Cellular Signatures Data Portal

The LINCS Data Portal provides a unified interface for searching LINCS dataset packages and reagents. LINCS data are being made openly available as a community resource through a series of data releases, so as to enable scientists to address a broad range of basic research questions and to facilitate the identification of biological targets for new disease therapies. LINCS datasets consist of assay results from cultured and primary human cells treated with bioactive small molecules, ligands such as growth factors and cytokines, or genetic perturbations. Many different assays are used to monitor cell responses, including assays measuring transcript and protein expression; cell phenotype data are captured by biochemical and imaging readouts. Assays are typically carried out on multiple cell types, and at multiple timepoints; perturbagen activity is monitored at multiple doses.LINCS数据门户（LINCS Data Portal）提供了统一的检索界面，用于查询LINCS数据集包与试剂。LINCS数据将以系列数据发布的形式作为社区资源公开共享，以期助力科学家解决各类基础研究问题，并推动新型疾病治疗相关生物学靶点的识别。LINCS数据集涵盖经生物活性小分子、生长因子与细胞因子等配体，或遗传扰动处理的培养细胞与原代人类细胞的检测结果。现有多种检测手段用于监测细胞应答，其中包括转录本与蛋白质表达检测；细胞表型数据则通过生化检测与成像读取结果获取。此类检测通常会在多种细胞类型、多个时间点下开展，并且会在多个剂量梯度下监测扰动因子的活性。

搜集汇总

背景与挑战

背景概述

LINCS数据门户是一个统一的搜索平台，提供来自人类细胞经生物活性小分子或遗传扰动处理后产生的检测结果数据集。它包含424个数据集，涵盖多种检测方法，如KINOMEscan和荧光成像，旨在支持基础研究和疾病治疗靶点识别。