Crystal structure of mouse PRMT6 in complex with inhibitor EML736
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Crystal structure of mouse PRMT6 in complex with inhibitor EML736 Descriptor: Protein arginine N-methyltransferase 6, methyl 6-[5-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]pentylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate Authors: Bonnefond, L, Cavarelli, J. Deposit date: 2021-03-11 Release date: 2022-03-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2 Å) Cite: Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J.Med.Chem., 65, 2022
创建时间：
2021-03-11
