A formulation dataset of poly(lactide-co-glycolide) nanoparticles for small molecule delivery

Poly(lactide-co-glycolide) (PLGA) nanoparticles are promising drug delivery systems, widely recognized for their ability to overcome various limitations associated with conventional formulations. Here, we present a literature-curated dataset of 433 PLGA nanoparticle formulations encompassing 65 small molecules, primarily drugs and drug-like compounds. For each formulation, the dataset includes 18 associated features that describe properties of the small molecule, excipients, and overall formulation characteristics. Additionally, three key performance metrics are provided: particle size, encapsulation efficiency (EE), and loading capacity (LC).